San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

SFGATE columnist Drew Magary isn't sure Purdy is good enough for the 49ers to pay up.

The San Francisco 49ers (6-10) and Arizona Cardinals (7-9) will look to wrap up their seasons on a high note when the meet ...

After a mostly healthy 2024, San Francisco 49ers quarterback Brock Purdy's season has come to an early end. Head coach Kyle ...

SANTA CLARA – With the 49ers eliminated from the playoffs after an injury-wrecked 2024 season, many San Francisco fans have already turned their attention to the offseason. Among the thousands ...

Watch the top defensive plays during Week 17 of the 2024 NFL season. Best plays from San Francisco 49ers rookie wide receiver ...

The NFL playoffs are just days away as 14 teams vie for a Super Bowl championship. Here's everything you need to know about ...

On Tuesday, the San Francisco 49ers placed linebacker Dre Greenlaw on the injured reserve list. It officially ends an abbreviated 2024 season for Greenlaw and it could also mean that the 49ers ...

Exits Week 18 game with knee issue ...

Watch the top catches from Week 17 of the 2024 NFL season. Best plays from San Francisco 49ers rookie wide receiver Ricky ...

The San Francisco 49ers suffered a heartbreaking 40-34 defeat to the Detroit Lions in their Week 17 matchup on "Monday Night Football." Despite being eliminated from playoff contention ...

The 49ers (6-10) could not keep pace with the playoff-bound Detroit Lions (14-2) and lost ...