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Nature Medicine | 胰腺癌的致命信号:KRAS突变剂量如何决定患者命运?
引言胰腺癌(Pancreatic cancer)是全球癌症相关死亡的第三大原因,其五年生存率低至10%,是一种预后极差的恶性肿瘤。胰腺导管腺癌(Pancreatic ductal adenocarcinoma, PDAC)是胰腺癌最常见的组织学类型,占所有病例的绝大多数。研究发现,超过90%的PDAC患者存在KRAS基因的活化突变(KRAS ...
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