Detroit Lions aim for NFC's top seed in rematch with San Francisco 49ers, while San Francisco plays out disappointing season.

Trent Williams' season has come to an end. San Francisco 49ers head coach Kyle Shanahan announced that the star left tackle ...

San Francisco 49ers left tackle Trent Williams, who has missed his team's last four games with an ankle injury, may sit the ...

LOS ANGELES — A California appeals court has overturned the rape conviction of former San Francisco 49er Dana Stubblefield ...

Juszczyk (illness) didn't practice Friday, Nick Wagoner of ESPN.com reports.

The rivalry comes to a big stage again, this time, it's Thursday Night Football. The Los Angeles Rams take on the San ...

The San Francisco 49ers fell short 29-17 to the Miami Dolphins on Sunday afternoon. The loss drops the red and gold to 6-9 on the year, and with several other NFC teams earning wins in Week 16 ...

All 49ers games can be heard on KGO (810-AM), The Bone (KSAN 107.7-FM) and the 49ers Radio Network. The live game broadcast featuring announcers Jesús Zárate and Carlos Yustis will be streamed ...

De’Vondre Campbell wouldn't go in when asked to replace a teammate during his team's loss to the rival Los Angeles Rams.