Way back in Week 4, 49ers rookie guard Dominick Puni had the wind knocked out of him and had to miss a snap. He hasn’t been ...

Who are the 10 greatest San Francisco 49ers of all time? FOX Sports Research compiled the list of Niner greats.

Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Monday's Lions-49ers game ...

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17’s game vs. the Lions ...

With nothing left to play for this season, the 49ers will have to hope that Brock Purdy grows from a challenging 2024 ...

This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from ...

The San Francisco 49ers are set to host the Detroit Lions at Levi's Stadium in Santa Clara, California, on Monday, December ...

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Saturday's practice as the team prepares for its Week ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 17 matchup vs. the Detroit Lions.