Way back in Week 4, 49ers rookie guard Dominick Puni had the wind knocked out of him and had to miss a snap. He hasn’t been ...

Who are the 10 greatest San Francisco 49ers of all time? FOX Sports Research compiled the list of Niner greats.

Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Monday's Lions-49ers game ...

RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17’s game vs. the Lions ...

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Monday Night Football game between Detroit Lions ...

This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from ...

The Detroit Lions and San Francisco 49ers will square off in a rematch of last year's NFC Championship game on Monday Night ...

The San Francisco 49ers are set to host the Detroit Lions at Levi's Stadium in Santa Clara, California, on Monday, December ...

The San Francisco 49ers have become the latest team to suffer the dreaded Super Bowl hangover. After a 12-5 season and a ...

The Niners are guaranteed a losing season after one of their worst performances of the ...

The 49ers have had a season filled with disappointment and one NFL writer believes they will look to the NFC to replace one ...

When do the Detroit Lions play today? The Lions are off Sunday and will play the San Francisco 49ers on Monday Night Football ...