Detroit Lions aim for NFC's top seed in rematch with San Francisco 49ers, while San Francisco plays out disappointing season.

San Francisco 49ers face tough decision on Trent Williams' season as injuries mount and playoff hopes dwindle.

1. ARIZONA CARDINALS: Kyler Murray, QB, Oklahoma: This has been no secret. Murray is going to Arizona unless the Raiders make a big-time move up to No. 1.

Christian McCaffrey is dealing with another long-term injury again. The San Francisco 49ers running back went down with a knee injury during the second quarter of the team's "Sunday Night Football ...

San Francisco 49ers coach Kyle Shanahan said linebacker De'Vondre Campbell won't be part of the team moving forward after he refused to enter a game after losing his starting job. Shanahan said ...

In a weird analogy for how the San Francisco 49ers season has gone compared to expectations, several fans of the team fought each other in the stands of Levi's Stadium during Thursday night's loss ...

The San Francisco 49ers plan to part ways with linebacker De'Vondre Campbell. Head coach Kyle Shanahan said during a conference call on Friday that the 49ers are making preparations to move on ...

A 38-13 victory over the woeful Chicago Bears ended the 49ers’ three-game losing streak, but now an extended win streak must follow for a legitimate playoff push. Related Articles San Francisco ...

SANTA CLARA -- The San Francisco 49ers just lost 12-6 to the Los Angeles Rams. Here are the 49ers' grades for this performance. It was one of the biggest games of Brock Purdy's career and also one ...

The San Francisco 49ers (6-7) will visit the Los Angeles Rams (7-6) in an NFC West showdown on Thursday Night Football. The Rams have won two straight games and six of their past eight.