The 49ers’ offensive line and running backs are incredibly banged up. That makes life difficult for San Francisco quarterback Brock Purdy. While the Lions are dealing with their own rash of injuries, Jared Goff and Detroit deliver and exact revenge in a game where they have much more at stake.

Check out these five of the best anytime TD prop bets for this NFL matchup between the 49ers and Lions on MNF. Find key stats and betting trends for this game.

Newsweek Sports' expert predictions for Detroit Lions vs. San Francisco 49ers on Monday Night Football Week 17.

It’s 49ers vs Lions in Week 17 of the 2024 NFL season. Here’s how to watch, including time, channel, TV schedule and streaming info.

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So, it’s come to this: no matter what the Detroit Lions do on Monday night in Week 17 against the San Francisco 49ers, they’ll be playing for the NFC North title against the Minnesota Vikings on Sunday night later this week, per the NFL schedule for Week 18. That also means the winner gets the No. 1 seed and an all-important bye week.